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Forschungsprojekt - Detailansicht

Bereich Bau und Umwelt - Fakultät Umweltwissenschaften - Fachrichtung Hydrowissenschaften - Institut für Hydrobiologie - Professur für Limnologie (Gewässerökologie)

Evolution und Ausbreitung von Antibiotikaresistenzgenen in Fließgewässersystemen
Titel (Englisch)
Evolution and spread of antibiotic resistance genes in running water systems
Kurzbeschreibung (Deutsch)
Running water ecosystems are matter of great importance concerning the spread and evolution of antibiotic resistance. On the one hand, streams are the connecting link between two nursery grounds of antibiotic resistance and on the other hand, they support the spatial proliferation of antibiotic resistance in the environment as well as the spread of those resistances within the bacterial community. Origins of antibiotic resistance traits are the natural or non clinical environment and clinical settings. In natural environments, those resistances were evolved for example for self protection of antibiotic producing organisms itself. In clinical settings, like treated patients where antibiotics act as a selective pressure, bacteria with hypermutable phenotype might be favourable selected as associated with the possibility to adapt rapidly to changing environment. Those two nursery grounds of antibiotic resistance are connected by the waste water pathway, where running waters hold the treated waste water and may serve as source for drinking water abstraction at other sites. In that context, running water ecosystems build up the environment where genetic interactions via horizontal gene transfer between bacteria originated in natural environments and human associated bacteria is expected. How is positive section of antibiotic resistance in stream ecosystems possible, even there is no selective pressure governed by antibiotics? The process responsible could be due to co-selection. There are four mechanisms able to cause co-selection. Genetic linkage of selectable traits (co-resistance), resistance mechanisms which mediate tolerance to different antimicrobial agents (cross-resistance) and co-regulative effects on different resistance mechanisms (co-regulation) could be responsible for co-selection. Furthermore, the biofilm phenotype has a high potential for divers resistances with proper conditions for horizontal gene transfer, thus able to support co-selection.
Kurzbeschreibung (Englisch)
Running water ecosystems are matter of great importance concerning the spread and evolution of antibiotic resistance. On the one hand, streams are the connecting link between two nursery grounds of antibiotic resistance and on the other hand, they support the spatial proliferation of antibiotic resistance in the environment as well as the spread of those resistances within the bacterial community. Origins of antibiotic resistance traits are the natural or non clinical environment and clinical settings. In natural environments, those resistances were evolved for example for self protection of antibiotic producing organisms itself. In clinical settings, like treated patients where antibiotics act as a selective pressure, bacteria with hypermutable phenotype might be favourable selected as associated with the possibility to adapt rapidly to changing environment. Those two nursery grounds of antibiotic resistance are connected by the waste water pathway, where running waters hold the treated waste water and may serve as source for drinking water abstraction at other sites. In that context, running water ecosystems build up the environment where genetic interactions via horizontal gene transfer between bacteria originated in natural environments and human associated bacteria is expected. How is positive section of antibiotic resistance in stream ecosystems possible, even there is no selective pressure governed by antibiotics? The process responsible could be due to co-selection. There are four mechanisms able to cause co-selection. Genetic linkage of selectable traits (co-resistance), resistance mechanisms which mediate tolerance to different antimicrobial agents (cross-resistance) and co-regulative effects on different resistance mechanisms (co-regulation) could be responsible for co-selection. Furthermore, the biofilm phenotype has a high potential for divers resistances with proper conditions for horizontal gene transfer, thus able to support co-selection.
Zeitraum
01.07.2010 - 30.06.2013
Art der Finanzierung
Drittmittel
Projektleiter
  • Herr Prof.Dr.rer.nat.habil. Thomas U. Berendonk
Weitere Leiter (außerhalb des Lehrstuhls)
Prof. Dr. M. Weitere (UFZ Leipzig)
Projektmitarbeiter
  • Frau Dipl.-Biol. Claudia Seiler
Finanzierungseinrichtungen
  • Helmholtz-Zentrum für Umweltforschung - UFZ
Kooperationspartnerschaft
international
Externe Kooperationspartner
  • Prof. Markus Weitere, Helmholtz-Zentrum für Umweltforschung - UFZ (Deutschland)
Zugeordnete Profillinie
Energie und Umwelt
Zugeordnetes Graduiertenkolleg
Helmholtz Graduate School "HIGRADE"
Zugeordnete BMBF-Spitzenforschung-Ost
IWAS - Internationale Wasserforschungs-Allianz Sachsen
Relevant für den Umweltschutz
Ja
Relevant für Multimedia
Nein
Relevant für den Technologietransfer
Nein
Schlagwörter
antibiotic resistance, co-selection, biofilm
Berichtsjahr
2013
Stand: 12.03.2014